VHA-19 IS ESSENTIAL IN CAENORHABDITIS ELEGANS OOCYTES FOR EMBRYOGENESIS AND IS INVOLVED IN TRAFFICKING IN OOCYTES.

VHA-19 is essential in Caenorhabditis elegans oocytes for embryogenesis and is involved in trafficking in oocytes.

There is an urgent need to develop new drugs against parasitic nematodes, which are a significant burden on human Health Care Products health and agriculture.Information about the function of essential nematode-specific genes provides insight to key nematode-specific processes that could be targeted with drugs.We have characterized the function of

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Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter.

K(+) channels share common selectivity characteristics but exhibit a wide diversity in how they are gated open.Leak K(2P) K(+) channels TASK-2, TALK-1 and TALK-2 are gated open by extracellular alkalinization.The mechanism for this alkalinization-dependent gating has been proposed to be the neutralization of the side chain of a single arginine (lys

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